Motif ID: FOX{D1,D2}.p2

Z-value: 3.199


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXD1hg19_v1_chr5_-_72744351_72744468-0.447.3e-05Click!
FOXD2hg19_v1_chr1_+_47901688_47901688-0.234.2e-02Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_95225802 55.855 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr22_-_31688329 34.068 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr17_-_46035109 32.626 NM_024320
PRR15L
proline rich 15-like
chrX_-_106960268 32.436 NM_004089
TSC22D3
TSC22 domain family, member 3
chrX_-_106960028 32.366 TSC22D3
TSC22 domain family, member 3
chr12_+_106696508 29.894 NM_152772
TCP11L2
t-complex 11 (mouse)-like 2
chr12_-_10573041 29.248 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr12_-_92539614 28.629 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr22_-_31686707 26.795 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr16_+_55512801 25.531 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr9_-_73028278 24.462 KLF9
Kruppel-like factor 9
chr2_-_192711923 23.746 NM_004657
SDPR
serum deprivation response
chr1_+_116654375 23.699 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr3_+_113616317 22.727 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr10_+_63808968 22.670 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr14_+_23067128 21.503 NM_022060
ABHD4
abhydrolase domain containing 4
chr10_+_99079017 20.977 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr5_-_42811959 20.632 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr5_+_78532338 20.622


chr5_+_78531848 20.588 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr12_-_10588543 20.372 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr2_-_192711651 20.132 SDPR
serum deprivation response
chr3_+_23987514 20.059 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr10_+_95848811 19.610 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr16_+_86612114 18.787 NM_005250
FOXL1
forkhead box L1
chr8_-_133772808 18.786 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr9_-_98269686 18.671 NM_001083606
PTCH1
patched 1
chr4_+_86396251 18.002 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr1_+_92545861 17.833 NM_183242
BTBD8
BTB (POZ) domain containing 8
chr4_-_141075232 17.706 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr7_+_106809405 17.466 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr3_+_23986735 17.033 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr3_+_69812620 16.762 NM_001184967
MITF
microphthalmia-associated transcription factor
chr12_-_91576805 16.438 NM_001920
DCN
decorin
chr16_-_30107492 16.270 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr6_-_30043547 16.262 NM_170769
NM_025236
RNF39

ring finger protein 39

chr6_+_89791510 15.871 PNRC1
proline-rich nuclear receptor coactivator 1
chr2_-_165424993 15.843 GRB14
growth factor receptor-bound protein 14
chr11_+_46402333 15.758 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr9_-_98269480 15.235 NM_001083607
PTCH1
patched 1
chr9_+_12775713 15.216 C9orf150
chromosome 9 open reading frame 150
chr11_+_10476665 15.142 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr17_+_9745847 14.849 GLP2R
glucagon-like peptide 2 receptor
chr17_+_57408907 14.652 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr1_+_145438437 14.571 NM_006472
TXNIP
thioredoxin interacting protein
chr19_+_18496966 14.498 NM_004864
GDF15
growth differentiation factor 15
chr17_+_58755158 13.739 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr2_+_132480063 13.351 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr14_+_24867926 13.238 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr14_-_23288912 13.227 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_-_188419185 13.195 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr6_-_56716412 13.081 DST
dystonin
chr5_-_95768660 13.036 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_-_182357871 12.940 GLUL
glutamate-ammonia ligase
chr1_-_45956795 12.926 NM_007170
TESK2
testis-specific kinase 2
chr4_+_74606222 12.847 NM_000584
IL8
interleukin 8
chr7_-_7575449 12.809 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr11_-_102826433 12.723 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr17_+_3379295 12.674 NM_000049
ASPA
aspartoacylase
chr11_+_33061291 12.549 TCP11L1
t-complex 11 (mouse)-like 1
chr12_-_91576579 12.405 DCN
decorin
chr3_-_57234279 12.403 NM_003865
HESX1
HESX homeobox 1
chr12_+_54410641 12.167 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_+_189157551 12.130 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr10_-_21186530 12.066 NM_006393
NEBL
nebulette
chr6_+_74405933 11.964 CD109
CD109 molecule
chr14_-_74551073 11.943 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr5_-_16509106 11.883 NM_019000
FAM134B
family with sequence similarity 134, member B
chr9_-_98279246 11.822 NM_001083602
NM_001083603
PTCH1

patched 1

chr6_+_139094656 11.707 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr10_-_92681025 11.648 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_1356823 11.635 NM_001145210
NM_001243535
NM_001243536
ANKRD65


ankyrin repeat domain 65


chr6_+_12290528 11.626 NM_001168319
NM_001955
EDN1

endothelin 1

chr4_+_87857394 11.523


chr1_+_33722158 11.238 NM_152493
ZNF362
zinc finger protein 362
chr10_-_92680784 11.215 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_69985750 11.159 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr2_+_191301020 11.155 MFSD6
major facilitator superfamily domain containing 6
chr2_-_214016332 11.155 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_+_210444154 11.080 MAP2
microtubule-associated protein 2
chr11_+_33061560 11.041 NM_001145541
TCP11L1
t-complex 11 (mouse)-like 1
chr2_-_71454200 10.982 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr15_-_34630203 10.980 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr13_-_41240607 10.897 NM_002015
FOXO1
forkhead box O1
chr19_-_20748540 10.834 NM_001159293
ZNF737
zinc finger protein 737
chr14_-_74551159 10.797 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr15_-_44828864 10.624


chr10_+_63661012 10.478 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr10_-_49482912 10.335 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr6_+_74405856 10.309 CD109
CD109 molecule
chr6_-_31550065 10.301 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr1_-_92351476 10.269 TGFBR3
transforming growth factor, beta receptor III
chr11_+_33060962 10.239 NM_018393
TCP11L1
t-complex 11 (mouse)-like 1
chr1_-_12677347 10.194 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_+_227127993 10.172 ADCK3
aarF domain containing kinase 3
chr2_+_97481977 10.152 NM_017623
NM_199078
CNNM3

cyclin M3

chr1_-_182357757 10.149 GLUL
glutamate-ammonia ligase
chr19_+_41725259 10.132 AXL
AXL receptor tyrosine kinase
chr7_+_90339146 10.122 CDK14
cyclin-dependent kinase 14
chr1_+_227127959 10.116 ADCK3
aarF domain containing kinase 3
chr11_+_20049128 10.075 NAV2
neuron navigator 2
chr12_+_6881669 10.068 NM_002286
LAG3
lymphocyte-activation gene 3
chr19_+_50380681 10.059 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr5_-_121814781 10.054


chr17_+_37896219 9.976 NM_001242443
GRB7
growth factor receptor-bound protein 7
chr1_-_92351613 9.955 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr19_+_41725098 9.893 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr15_-_34629941 9.855 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr19_+_41725131 9.828 AXL
AXL receptor tyrosine kinase
chr19_+_41725277 9.825 AXL
AXL receptor tyrosine kinase
chr7_+_30174343 9.760 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr2_+_201450579 9.679 AOX1
aldehyde oxidase 1
chr17_-_67138013 9.667 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_+_74405764 9.627 CD109
CD109 molecule
chr13_+_97874704 9.627 MBNL2
muscleblind-like 2 (Drosophila)
chr10_-_99094427 9.595 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr19_-_7293876 9.477 NM_000208
NM_001079817
INSR

insulin receptor

chr2_-_163099877 9.458 NM_004460
FAP
fibroblast activation protein, alpha
chr15_-_60884615 9.443 NM_134262
RORA
RAR-related orphan receptor A
chr6_+_74405909 9.434 CD109
CD109 molecule
chr3_-_48956817 9.340 NM_001123040
C3orf71
chromosome 3 open reading frame 71
chr19_+_41725135 9.291 AXL
AXL receptor tyrosine kinase
chr12_+_120740123 9.227 NM_012240
SIRT4
sirtuin 4
chr5_-_150460599 9.217 NM_001252385
NM_001252386
NM_001252393
NM_006058
TNIP1



TNFAIP3 interacting protein 1



chr1_+_227127999 9.157 ADCK3
aarF domain containing kinase 3
chr5_-_150460550 9.121 TNIP1
TNFAIP3 interacting protein 1
chr6_+_32122194 9.117 PPT2
palmitoyl-protein thioesterase 2
chr12_+_1726221 9.026 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr16_+_53469519 8.959 RBL2
retinoblastoma-like 2 (p130)
chr3_+_54156691 8.884 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chrX_-_15683153 8.725 NM_020665
TMEM27
transmembrane protein 27
chr15_-_52970808 8.724 NM_019600
FAM214A
family with sequence similarity 214, member A
chr20_+_62887046 8.714 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr2_-_214015053 8.667 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr12_-_91573264 8.634 NM_133503
DCN
decorin
chr2_-_26205437 8.529 NM_002254
KIF3C
kinesin family member 3C
chr1_+_209878135 8.415 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr3_+_54156573 8.407 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr14_-_91526912 8.390 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr12_-_57704245 8.310 NM_014925
R3HDM2
R3H domain containing 2
chr2_-_26205327 8.266 KIF3C
kinesin family member 3C
chr1_-_108231122 8.264 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr6_+_74405505 8.207 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chrX_+_70315637 8.205 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr14_-_73493744 8.172 NM_021260
ZFYVE1
zinc finger, FYVE domain containing 1
chr7_+_91570150 8.114 NM_005751
NM_147185
AKAP9

A kinase (PRKA) anchor protein (yotiao) 9

chr6_+_149068148 8.106 NM_005715
UST
uronyl-2-sulfotransferase
chr12_+_32687246 8.083 FGD4
FYVE, RhoGEF and PH domain containing 4
chr11_+_117049838 8.068 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr2_-_216259197 7.985 FN1
fibronectin 1
chr2_-_122159140 7.983 CLASP1
cytoplasmic linker associated protein 1
chr17_+_72427535 7.969 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr6_+_32121775 7.952 NM_001204103
NM_005155
PPT2-EGFL8
PPT2

PPT2-EGFL8 readthrough
palmitoyl-protein thioesterase 2

chr3_+_38035077 7.928 NM_015873
VILL
villin-like
chr5_+_72251874 7.914 FCHO2
FCH domain only 2
chr4_-_74486100 7.911 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr6_-_152623213 7.909 SYNE1
spectrin repeat containing, nuclear envelope 1
chr17_-_8059637 7.887 PER1
period homolog 1 (Drosophila)
chr3_-_187452669 7.876 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr3_+_188889762 7.875 NM_198485
TPRG1
tumor protein p63 regulated 1
chr1_+_51435911 7.862 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr17_-_19648924 7.844 NM_001135167
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr2_-_99917638 7.818 NM_174898
LYG1
lysozyme G-like 1
chr2_-_208890207 7.757 NM_001080475
PLEKHM3
pleckstrin homology domain containing, family M, member 3
chr1_+_65730423 7.754 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr14_+_50234907 7.732 KLHDC2
kelch domain containing 2
chr1_+_227127937 7.718 NM_020247
ADCK3
aarF domain containing kinase 3
chr17_-_40897025 7.712 NM_001991
EZH1
enhancer of zeste homolog 1 (Drosophila)
chr9_+_136287443 7.691 ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr19_+_18111923 7.597 NM_001025604
ARRDC2
arrestin domain containing 2
chr17_-_65241276 7.591 HELZ
helicase with zinc finger
chr22_+_50609159 7.576 NM_001160300
NM_052839
PANX2

pannexin 2

chr19_+_52873169 7.515 NM_001145434
ZNF880
zinc finger protein 880
chr8_-_28243941 7.515 NM_018660
ZNF395
zinc finger protein 395
chr9_+_129724503 7.498 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr5_-_142782754 7.491 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr2_+_65283485 7.458 NM_015147
CEP68
centrosomal protein 68kDa
chr21_-_43816123 7.448 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr11_-_66335958 7.382 NM_003793
CTSF
cathepsin F
chr4_-_82393025 7.351 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr16_+_84150634 7.341 LOC729887
uncharacterized LOC729887
chr5_+_72251869 7.339


chr11_-_104916041 7.307 NM_001017534
NM_052889
CARD16

caspase recruitment domain family, member 16

chr6_-_33168369 7.290 NM_021976
RXRB
retinoid X receptor, beta
chr1_+_181002560 7.288 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr12_-_7245006 7.272 NM_001733
C1R
complement component 1, r subcomponent
chr11_-_71752099 7.269 NUMA1
nuclear mitotic apparatus protein 1
chr10_+_51549552 7.234 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr2_+_149402559 7.180 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr1_+_222886728 7.098 BROX
BRO1 domain and CAAX motif containing
chr17_-_65241305 7.080 NM_014877
HELZ
helicase with zinc finger
chr7_-_112579726 7.002 NM_152556
C7orf60
chromosome 7 open reading frame 60
chr19_-_47734215 6.995 NM_014417
BBC3
BCL2 binding component 3
chr20_+_21106623 6.970 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr1_-_24469571 6.945 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr6_-_56716713 6.940 DST
dystonin
chr3_-_99833348 6.931 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr4_-_103682126 6.914 MANBA
mannosidase, beta A, lysosomal
chr2_-_190044330 6.896 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_-_3221385 6.822 CRBN
cereblon

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.17 1.14e-02 GO:0007167 enzyme linked receptor protein signaling pathway
2.12 4.19e-02 GO:0009725 response to hormone stimulus
2.22 4.92e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
25.08 3.42e-02 GO:0043559 insulin binding
5.25 4.17e-02 GO:0005097 Rab GTPase activator activity